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Structural basis for pure antagonism of integrin αVβ3 by a high affinity form of fibronectin
Integrins are important therapeutic targets. However, current RGD-based anti-integrin drugs are also partial agonists, inducing conformational changes that trigger potentially fatal immune reactions and paradoxical cell adhesion. Here we describe the first crystal structure of αVβ3 bound to a physio...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4012256/ https://ncbi.nlm.nih.gov/pubmed/24658351 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2797 |
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