Structure-guided design of pure orthosteric inhibitors of αIIbβ3 that prevent thrombosis but preserve hemostasis

A prevailing dogma is that inhibition of vascular thrombosis by antagonizing platelet integrin αIIbβ3 cannot be achieved without compromising hemostasis, thus causing serious bleeding and increased morbidity and mortality. It is speculated that these adverse outcomes result from drug-induced activat...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Adair, Brian D., Alonso, José L., van Agthoven, Johannes, Hayes, Vincent, Ahn, Hyun Sook, Yu, I-Shing, Lin, Shu-Wha, Xiong, Jian-Ping, Poncz, Mortimer, Arnaout, M. Amin
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6972956/
https://ncbi.nlm.nih.gov/pubmed/31964886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13928-2
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