Structure-guided design of pure orthosteric inhibitors of αIIbβ3 that prevent thrombosis but preserve hemostasis

A prevailing dogma is that inhibition of vascular thrombosis by antagonizing platelet integrin αIIbβ3 cannot be achieved without compromising hemostasis, thus causing serious bleeding and increased morbidity and mortality. It is speculated that these adverse outcomes result from drug-induced activat...

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Publicat a:Nat Commun
Autors principals: Adair, Brian D., Alonso, José L., van Agthoven, Johannes, Hayes, Vincent, Ahn, Hyun Sook, Yu, I-Shing, Lin, Shu-Wha, Xiong, Jian-Ping, Poncz, Mortimer, Arnaout, M. Amin
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6972956/
https://ncbi.nlm.nih.gov/pubmed/31964886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13928-2
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