The α-Subunit Regulates Stability of the Metal Ion at the Ligand-associated Metal Ion-binding Site in β(3) Integrins

Bằng Rui, Xianliang, Mehrbod, Mehrdad, Van Agthoven, Johannes F., Anand, Saurabh, Xiong, Jian-Ping, Mofrad, Mohammad R. K., Arnaout, M. Amin
Được phát hành 2014

Structural basis for pure antagonism of integrin αVβ3 by a high affinity form of fibronectin

Bằng Van Agthoven, Johannes F., Xiong, Jian-Ping, Alonso, José Luis, Rui, Xianliang, Adair, Brian D., Goodman, Simon L., Arnaout, M. Amin
Được phát hành 2014

Structure-guided design of pure orthosteric inhibitors of αIIbβ3 that prevent thrombosis but preserve hemostasis

Bằng Adair, Brian D., Alonso, José L., van Agthoven, Johannes, Hayes, Vincent, Ahn, Hyun Sook, Yu, I-Shing, Lin, Shu-Wha, Xiong, Jian-Ping, Poncz, Mortimer, Arnaout, M. Amin
Xuất bản năm Nat Commun (2020)

Atomic Basis for the Species-specific Inhibition of αV Integrins by Monoclonal Antibody 17E6 Is Revealed by the Crystal Structure of αVβ3 Ectodomain-17E6 Fab Complex

Bằng Mahalingam, Bhuvaneshwari, Van Agthoven, Johannes F., Xiong, Jian-Ping, Alonso, José Luis, Adair, Brian D., Rui, Xianliang, Anand, Saurabh, Mehrbod, Mehrdad, Mofrad, Mohammad R. K., Burger, Christa, Goodman, Simon L., Arnaout, M. Amin
Được phát hành 2014

Structural basis of the differential binding of engineered knottins to integrins αVβ3 and α5β1

Bằng Van Agthoven, Johannes F., Shams, Hengameh, Cochran, Frank V., Alonso, José L., Kintzing, James R., Garakani, Kiavash, Adair, Brian D., Xiong, Jian-Ping, Mofrad, Mohammad R. K., Cochran, Jennifer R., Arnaout, M. Amin
Xuất bản năm Structure (2019)

Novel Pure αVβ3 Integrin Antagonists That Do Not Induce Receptor Extension, Prime the Receptor, or Enhance Angiogenesis at Low Concentrations

Bằng Li, Jihong, Fukase, Yoshiyuki, Shang, Yi, Zou, Wei, Muñoz-Félix, José M., Buitrago, Lorena, van Agthoven, Johannes, Zhang, Yixiao, Hara, Ryoma, Tanaka, Yuta, Okamoto, Rei, Yasui, Takeshi, Nakahata, Takashi, Imaeda, Toshihiro, Aso, Kazuyoshi, Zhou, Yuchen, Locuson, Charles, Nesic, Dragana, Duggan, Mark, Takagi, Junichi, Vaughan, Roger D., Walz, Thomas, Hodivala-Dilke, Kairbaan, Teitelbaum, Steven L., Arnaout, M. Amin, Filizola, Marta, Foley, Michael A., Coller, Barry S.
Xuất bản năm ACS Pharmacol Transl Sci (2019)