Indirect targeting of IGF receptor signaling in vivo by substrate-selective inhibition of PAPP-A proteolytic activity

The insulin-like growth factor (IGF) signaling pathway is involved in certain human cancers, and the feasibility of directly targeting the IGF receptor has been actively investigated. However, recent evidence from clinical trials suggests that this approach can be problematic. We have developed an a...

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Bibliografische gegevens
Hoofdauteurs: Mikkelsen, Jakob H., Resch, Zachary T., Kalra, Bhanu, Savjani, Gopal, Kumar, Ajay, Conover, Cheryl A., Oxvig, Claus
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Impact Journals LLC 2014
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Research Paper
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4011579/
https://ncbi.nlm.nih.gov/pubmed/24572990
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