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Indirect targeting of IGF receptor signaling in vivo by substrate-selective inhibition of PAPP-A proteolytic activity

The insulin-like growth factor (IGF) signaling pathway is involved in certain human cancers, and the feasibility of directly targeting the IGF receptor has been actively investigated. However, recent evidence from clinical trials suggests that this approach can be problematic. We have developed an a...

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Detalhes bibliográficos
Main Authors: Mikkelsen, Jakob H., Resch, Zachary T., Kalra, Bhanu, Savjani, Gopal, Kumar, Ajay, Conover, Cheryl A., Oxvig, Claus
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4011579/
https://ncbi.nlm.nih.gov/pubmed/24572990
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