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p53-mediated heterochromatin reorganization regulates its cell fate decisions
p53 is a major sensor of cellular stresses, and its activation influences cell fate decisions. We identified SUV39H1, a histone code ‘writer’ responsible for the histone H3 Lys9 trimethylation (H3K9me3) mark for ‘closed’ chromatin conformation, as a target of p53 repression. SUV39H1 downregulation w...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4009975/ https://ncbi.nlm.nih.gov/pubmed/22466965 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2271 |
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