USP7 enforces heterochromatinization of p53 target promoters by protecting SUV39H1 (KMT1A) from MDM2-mediated degradation

The H3K9me3 repressive histone conformation of p53 target promoters is abrogated in response to p53 activation by MDM2-mediated SUV39H1 degradation. Here, we present evidence that the USP7 deubiquitinase protects SUV39H1 from MDM2-mediated ubiquitination in the absence of p53 stimulus. USP7 occupies...

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Detaylı Bibliyografya
Yayımlandı:Cell Rep
Asıl Yazarlar: Mungamuri, Sathish Kumar, Qiao, Rui F., Yao, Shen, Manfredi, James J., Gu, Wei, Aaronson, Stuart A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2016
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4884055/
https://ncbi.nlm.nih.gov/pubmed/26971997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.02.049
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