Effect of chirality and lipophilicity in the functional activity of evodiamine and its analogues at TRPV1 channels

BACKGROUND AND PURPOSE: Evodiamine, a racemic quinazolinocarboline alkaloid isolated from the traditional Chinese medicine Evodiae fructus, has been reported to act as an agonist of the transient receptor potential vanilloid type-1 (TRPV1) cation channel both in vitro and in vivo. Evodiamine is stru...

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Detalhes bibliográficos
Main Authors: De Petrocellis, Luciano, Schiano Moriello, Aniello, Fontana, Gabriele, Sacchetti, Alessandro, Passarella, Daniele, Appendino, Giovanni, Di Marzo, Vincenzo
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2014
Assuntos:
Themed Section: The Pharmacology of Trp Channels
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4009003/
https://ncbi.nlm.nih.gov/pubmed/23902373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12320
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