Halogenation of a capsaicin analogue leads to novel vanilloid TRPV1 receptor antagonists

1. The C-5 halogenation of the vanillyl moiety of resiniferatoxin, an ultrapotent agonist of vanilloid TRPV1 receptors, results in a potent antagonist for these receptors. Here, we have synthesized a series of halogenated derivatives of ‘synthetic capsaicin' (nonanoyl vanillamide=nordihydrocaps...

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Bibliografiske detaljer
Main Authors: Appendino, Giovanni, Harrison, Selena, De Petrocellis, Luciano, Daddario, Nives, Bianchi, Federica, Schiano Moriello, Aniello, Trevisani, Marcello, Benvenuti, Francesca, Geppetti, Pierangelo, Di Marzo, Vincenzo
Format: Artigo
Sprog:Inglês
Udgivet: 2003
Fag:
Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1573981/
https://ncbi.nlm.nih.gov/pubmed/12922928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0705387
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