Design, Synthesis and In Vitro Experimental Validation of Novel TRPV4 Antagonists Inspired by Labdane Diterpenes

Labdane diterpenes are widespread classes of natural compounds present in variety of marine and terrestrial organisms and plants. Many of them represents “natural libraries” of compounds with interesting biological activities due to differently functionalized drimane nucleus exploitable for potentia...

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Bibliographische Detailangaben
Hauptverfasser: Sarah Mazzotta, Gabriele Carullo, Aniello Schiano Moriello, Pietro Amodeo, Vincenzo Di Marzo, Margarita Vega-Holm, Rosa Maria Vitale, Francesca Aiello, Antonella Brizzi, Luciano De Petrocellis
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI AG 2020-10-01
Schriftenreihe:Marine Drugs
Schlagworte:
labdane scaffold
bioactive diterpenes
sclareolide
structure-activity relationships
TRPV4 channel
amides/esters
Online Zugang:https://www.mdpi.com/1660-3397/18/10/519
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