A re-evaluation of 9-HODE activity at TRPV1 channels in comparison with anandamide: enantioselectivity and effects at other TRP channels and in sensory neurons

BACKGROUND AND PURPOSE: Two oxidation products of linoleic acid, 9- and 13-hydroxy-octadecadienoic acids (HODEs), have recently been suggested to act as endovanilloids, that is, endogenous agonists of transient receptor potential vanilloid-1 (TRPV1) channels, thereby contributing to inflammatory hyp...

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Autores principales: De Petrocellis, Luciano, Schiano Moriello, Aniello, Imperatore, Roberta, Cristino, Luigia, Starowicz, Katarzyna, Di Marzo, Vincenzo
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Publishing Ltd 2012
Materias:
Themed Section: Research Papers
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3525867/
https://ncbi.nlm.nih.gov/pubmed/22861649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2012.02122.x
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