Discovery of 4,4-Disubstituted Quinazolin-2-ones as T-Type Calcium Channel Antagonists

[Image: see text] A novel series of quinazolinone T-type calcium channel antagonists have been prepared and evaluated using in vitro and in vivo assays. Optimization of the screening hit 3 by modifications of the 3- and 4-positions of the quinazolinone ring afforded potent and selective antagonists...

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Detaylı Bibliyografya
Asıl Yazarlar: Barrow, James C., Rittle, Kenneth E., Reger, Thomas S., Yang, Zhi-Qiang, Bondiskey, Phung, McGaughey, Georgia B., Bock, Mark G., Hartman, George D., Tang, Cuyue, Ballard, Jeanine, Kuo, Yuhsin, Prueksaritanont, Thomayant, Nuss, Cindy E., Doran, Scott M., Fox, Steven V., Garson, Susan L., Kraus, Richard L., Li, Yuxing, Marino, Michael J., Kuzmick Graufelds, Valerie, Uebele, Victor N., Renger, John J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Chemical Society 2010
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4007971/
https://ncbi.nlm.nih.gov/pubmed/24900180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml100004r
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