Discovery of 4,4-Disubstituted Quinazolin-2-ones as T-Type Calcium Channel Antagonists

[Image: see text] A novel series of quinazolinone T-type calcium channel antagonists have been prepared and evaluated using in vitro and in vivo assays. Optimization of the screening hit 3 by modifications of the 3- and 4-positions of the quinazolinone ring afforded potent and selective antagonists...

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Main Authors: Barrow, James C., Rittle, Kenneth E., Reger, Thomas S., Yang, Zhi-Qiang, Bondiskey, Phung, McGaughey, Georgia B., Bock, Mark G., Hartman, George D., Tang, Cuyue, Ballard, Jeanine, Kuo, Yuhsin, Prueksaritanont, Thomayant, Nuss, Cindy E., Doran, Scott M., Fox, Steven V., Garson, Susan L., Kraus, Richard L., Li, Yuxing, Marino, Michael J., Kuzmick Graufelds, Valerie, Uebele, Victor N., Renger, John J.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2010
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4007971/
https://ncbi.nlm.nih.gov/pubmed/24900180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml100004r
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