Short-Acting T-Type Calcium Channel Antagonists Significantly Modify Sleep Architecture in Rodents

[Image: see text] A novel phenyl acetamide series of short-acting T-type calcium channel antagonists has been identified and evaluated using in vitro and in vivo assays. Heterocycle substitutions of the 4-position of the phenyl acetamides afforded potent and selective antagonists that exhibited desi...

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Main Authors: Yang, Zhi-Qiang, Schlegel, Kelly-Ann S., Shu, Youheng, Reger, Thomas S., Cube, Rowena, Mattern, Christa, Coleman, Paul J., Small, Jim, Hartman, George D., Ballard, Jeanine, Tang, Cuyue, Kuo, Yuhsin, Prueksaritanont, Thomayant, Nuss, Cindy E., Doran, Scott, Fox, Steve V., Garson, Susan L., Li, Yuxing, Kraus, Richard L., Uebele, Victor N., Taylor, Adekemi B., Zeng, Wei, Fang, Wei, Chavez-Eng, Cynthia, Troyer, Matthew D., Luk, Julie Ann, Laethem, Tine, Cook, William O., Renger, John J., Barrow, James C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2010
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4007914/
https://ncbi.nlm.nih.gov/pubmed/24900239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml100170e
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