Reshaping Antibody Diversity

Unlike humans or mice, some species have limited genome encoded combinatorial diversity potential, yet mount a robust antibody response. Cows are unusual in having exceptionally long CDR H3 loops and few V-regions, but the mechanism for creating diversity is not understood. Deep sequencing revealed...

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Main Authors: Wang, Feng, Ekiert, Damian C., Ahmad, Insha, Yu, Wenli, Zhang, Yong, Bazirgan, Omar, Torkamani, Ali, Raudsepp, Terje, Mwangi, Waithaka, Criscitiello, Michael F., Wilson, Ian A., Schultz, Peter G., Smider, Vaughn V.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4007204/
https://ncbi.nlm.nih.gov/pubmed/23746848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2013.04.049
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