Fatty acids increase neuronal hypertrophy of Pten knockdown neurons

Phosphatase and tensin homolog (Pten) catalyzes the reverse reaction of PI3K by dephosphorylating PIP3 to PIP2. This negatively regulates downstream Akt/mTOR/S6 signaling resulting in decreased cellular growth and proliferation. Co-injection of a lentivirus knocking Pten down with a control lentivir...

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Autores principales: Fricano, Catherine J., DeSpenza, Tyrone, Frazel, Paul W., Li, Meijie, O'Malley, A. James, Westbrook, Gary L., Luikart, Bryan W.
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2014
Materias:
Neuroscience
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4006057/
https://ncbi.nlm.nih.gov/pubmed/24795563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2014.00030
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