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Nuclear-Excluded Autism-Associated PTEN Mutations Dysregulate Neuronal Growth
BACKGROUND: Phosphatase and tensin homolog (PTEN) negatively regulates downstream AKT signaling resulting in decreased cellular growth and proliferation. PTEN is mutated in a subset of children with autism spectrum disorder (ASD); however, the mechanism by which specific point mutations alter PTEN f...
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| Gepubliceerd in: | Biol Psychiatry |
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| Hoofdauteurs: | , , , , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2017
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5984669/ https://ncbi.nlm.nih.gov/pubmed/29373119 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2017.11.025 |
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