Nuclear-Excluded Autism-Associated PTEN Mutations Dysregulate Neuronal Growth

BACKGROUND: Phosphatase and tensin homolog (PTEN) negatively regulates downstream AKT signaling resulting in decreased cellular growth and proliferation. PTEN is mutated in a subset of children with autism spectrum disorder (ASD); however, the mechanism by which specific point mutations alter PTEN f...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Biol Psychiatry
Prif Awduron: Fricano-Kugler, Catherine J., Getz, Stephanie A., Williams, Michael R., Zurawel, Ashley A., DeSpenza, Tyrone, Frazel, Paul W., Li, Meijie, O’Malley, Alistair J., Moen, Erika L., Luikart, Bryan W.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2017
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5984669/
https://ncbi.nlm.nih.gov/pubmed/29373119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2017.11.025
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg