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CD28 and ITK signals regulate autoreactive T cell trafficking
Activation of self-reactive T cells and their trafficking to target tissues leads to autoimmune organ destruction. Mice lacking the coinhibitory receptor CTLA-4 develop fatal autoimmunity characterized by massive lymphocytic invasion into non-lymphoid tissues. Here we demonstrate that the CD28 costi...
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| Main Authors: | , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4005518/ https://ncbi.nlm.nih.gov/pubmed/24270545 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3393 |
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