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The Tec kinase ITK regulates thymic expansion, emigration, and maturation of γδ NKT cells
The Tec family tyrosine kinase, Itk, regulates signaling downstream of the T cell receptor (TCR). The absence of Itk in CD4(+) T cells results in impaired Th2 responses along with defects in maturation, cytokine production and survival of iNKT cells. Paradoxically, Itk(−/−) mice have spontaneously e...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3594397/ https://ncbi.nlm.nih.gov/pubmed/23378428 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1202531 |
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