CD28 and ITK signals regulate autoreactive T cell trafficking

Activation of self-reactive T cells and their trafficking to target tissues leads to autoimmune organ destruction. Mice lacking the coinhibitory receptor CTLA-4 develop fatal autoimmunity characterized by massive lymphocytic invasion into non-lymphoid tissues. Here we demonstrate that the CD28 costi...

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Bibliographische Detailangaben
Hauptverfasser: Jain, Nitya, Miu, Bing, Jiang, Jian-kang, McKinstry, Kai K., Prince, Amanda, Swain, Susan L, Greiner, Dale L., Thomas, Craig J., Sanderson, Michael J., Berg, Leslie J, Kang, Joonsoo
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4005518/
https://ncbi.nlm.nih.gov/pubmed/24270545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3393
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