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Tet3-Mediated Hydroxymethylation of Epigenetically Silenced Genes Contributes to Bone Morphogenic Protein 7-Induced Reversal of Kidney Fibrosis

Methylation of CpG island promoters is an epigenetic event that can effectively silence transcription over multiple cell generations. Hypermethylation of the Rasal1 promoter contributes to activation of fibroblasts and progression of kidney fibrosis. Here, we explored whether such causative hypermet...

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Bibliografski detalji
Glavni autori: Tampe, Björn, Tampe, Desiree, Müller, Claudia A., Sugimoto, Hikaru, LeBleu, Valerie, Xu, Xingbo, Müller, Gerhard A., Zeisberg, Elisabeth M., Kalluri, Raghu, Zeisberg, Michael
Format: Artigo
Jezik:Inglês
Izdano: American Society of Nephrology 2014
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4005308/
https://ncbi.nlm.nih.gov/pubmed/24480825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2013070723
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