Tet3-Mediated Hydroxymethylation of Epigenetically Silenced Genes Contributes to Bone Morphogenic Protein 7-Induced Reversal of Kidney Fibrosis

Methylation of CpG island promoters is an epigenetic event that can effectively silence transcription over multiple cell generations. Hypermethylation of the Rasal1 promoter contributes to activation of fibroblasts and progression of kidney fibrosis. Here, we explored whether such causative hypermet...

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Detaylı Bibliyografya
Asıl Yazarlar: Tampe, Björn, Tampe, Desiree, Müller, Claudia A., Sugimoto, Hikaru, LeBleu, Valerie, Xu, Xingbo, Müller, Gerhard A., Zeisberg, Elisabeth M., Kalluri, Raghu, Zeisberg, Michael
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society of Nephrology 2014
Konular:
Brief Communications
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4005308/
https://ncbi.nlm.nih.gov/pubmed/24480825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2013070723
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