Tet3-Mediated Hydroxymethylation of Epigenetically Silenced Genes Contributes to Bone Morphogenic Protein 7-Induced Reversal of Kidney Fibrosis

Methylation of CpG island promoters is an epigenetic event that can effectively silence transcription over multiple cell generations. Hypermethylation of the Rasal1 promoter contributes to activation of fibroblasts and progression of kidney fibrosis. Here, we explored whether such causative hypermet...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Tampe, Björn, Tampe, Desiree, Müller, Claudia A., Sugimoto, Hikaru, LeBleu, Valerie, Xu, Xingbo, Müller, Gerhard A., Zeisberg, Elisabeth M., Kalluri, Raghu, Zeisberg, Michael
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Society of Nephrology 2014
विषय:
Brief Communications
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC4005308/
https://ncbi.nlm.nih.gov/pubmed/24480825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2013070723
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