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Tet3-Mediated Hydroxymethylation of Epigenetically Silenced Genes Contributes to Bone Morphogenic Protein 7-Induced Reversal of Kidney Fibrosis

Methylation of CpG island promoters is an epigenetic event that can effectively silence transcription over multiple cell generations. Hypermethylation of the Rasal1 promoter contributes to activation of fibroblasts and progression of kidney fibrosis. Here, we explored whether such causative hypermet...

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Main Authors: Tampe, Björn, Tampe, Desiree, Müller, Claudia A., Sugimoto, Hikaru, LeBleu, Valerie, Xu, Xingbo, Müller, Gerhard A., Zeisberg, Elisabeth M., Kalluri, Raghu, Zeisberg, Michael
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society of Nephrology 2014
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4005308/
https://ncbi.nlm.nih.gov/pubmed/24480825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2013070723
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