Trimethylation of Histone H3 Lysine 36 by Human Methyltransferase PRDM9 Protein

PRDM9 (PR domain-containing protein 9) is a meiosis-specific protein that trimethylates H3K4 and controls the activation of recombination hot spots. It is an essential enzyme in the progression of early meiotic prophase. Disruption of the PRDM9 gene results in sterility in mice. In human, several PR...

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Hlavní autoři: Eram, Mohammad S., Bustos, Susan P., Lima-Fernandes, Evelyne, Siarheyeva, Alena, Senisterra, Guillermo, Hajian, Taraneh, Chau, Irene, Duan, Shili, Wu, Hong, Dombrovski, Ludmila, Schapira, Matthieu, Arrowsmith, Cheryl H., Vedadi, Masoud
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2014
Témata:
Enzymology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4002121/
https://ncbi.nlm.nih.gov/pubmed/24634223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.523183
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