Reversal of SIN-1-induced eNOS dysfunction by the spin trap, DMPO, in bovine aortic endothelial cells via eNOS phosphorylation

BACKGROUND AND PURPOSE: Nitric oxide (NO) derived from eNOS is mostly responsible for the maintenance of vascular homeostasis and its decreased bioavailability is characteristic of reactive oxygen species (ROS)-induced endothelial dysfunction (ED). Because 5,5-dimethyl-1-pyrroline-N-oxide (DMPO), a...

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Main Authors: Das, Amlan, Gopalakrishnan, Bhavani, Druhan, Lawrence J, Wang, Tse-Yao, De Pascali, Francesco, Rockenbauer, Antal, Racoma, Ira, Varadharaj, Saradhadevi, Zweier, Jay L, Cardounel, Arturo J, Villamena, Frederick A
Format: Artigo
Sprog:Inglês
Udgivet: BlackWell Publishing Ltd 2014
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3997273/
https://ncbi.nlm.nih.gov/pubmed/24405159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12572
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