Yeast reveal a “druggable” Rsp5/Nedd4 Network that Ameliorates α–Synuclein Toxicity in Neurons

α–synuclein (α-syn) is a small lipid binding protein implicated in several neurodegenerative diseases, including Parkinson’s disease, whose pathobiology is conserved from yeast to man. There are no therapies targeting these underlying cellular pathologies, or indeed those of any major neurodegenerat...

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Hlavní autoři: Tardiff, Daniel F., Jui, Nathan T., Khurana, Vikram, Tambe, Mitali A., Thompson, Michelle L., Chung, Chee Yeun, Kamadurai, Hari B., Kim, Hyoung Tae, Lancaster, Alex K., Caldwell, Kim A., Caldwell, Guy A., Rochet, Jean-Christophe, Buchwald, Stephen L., Lindquist, Susan
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3993916/
https://ncbi.nlm.nih.gov/pubmed/24158909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1245321
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