Yeast reveal a “druggable” Rsp5/Nedd4 Network that Ameliorates α–Synuclein Toxicity in Neurons

α–synuclein (α-syn) is a small lipid binding protein implicated in several neurodegenerative diseases, including Parkinson’s disease, whose pathobiology is conserved from yeast to man. There are no therapies targeting these underlying cellular pathologies, or indeed those of any major neurodegenerat...

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Detalhes bibliográficos
Main Authors: Tardiff, Daniel F., Jui, Nathan T., Khurana, Vikram, Tambe, Mitali A., Thompson, Michelle L., Chung, Chee Yeun, Kamadurai, Hari B., Kim, Hyoung Tae, Lancaster, Alex K., Caldwell, Kim A., Caldwell, Guy A., Rochet, Jean-Christophe, Buchwald, Stephen L., Lindquist, Susan
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3993916/
https://ncbi.nlm.nih.gov/pubmed/24158909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1245321
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