Yeast reveal a “druggable” Rsp5/Nedd4 Network that Ameliorates α–Synuclein Toxicity in Neurons

α–synuclein (α-syn) is a small lipid binding protein implicated in several neurodegenerative diseases, including Parkinson’s disease, whose pathobiology is conserved from yeast to man. There are no therapies targeting these underlying cellular pathologies, or indeed those of any major neurodegenerat...

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Главные авторы: Tardiff, Daniel F., Jui, Nathan T., Khurana, Vikram, Tambe, Mitali A., Thompson, Michelle L., Chung, Chee Yeun, Kamadurai, Hari B., Kim, Hyoung Tae, Lancaster, Alex K., Caldwell, Kim A., Caldwell, Guy A., Rochet, Jean-Christophe, Buchwald, Stephen L., Lindquist, Susan
Формат: Artigo
Язык:Inglês
Опубликовано: 2013
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3993916/
https://ncbi.nlm.nih.gov/pubmed/24158909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1245321
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