Length-dependent activation is modulated by cardiac troponin I bisphosphorylation at Ser23 and Ser24 but not by Thr143 phosphorylation

Frank-Starling's law reflects the ability of the heart to adjust the force of its contraction to changes in ventricular filling, a property based on length-dependent myofilament activation (LDA). The threonine at amino acid 143 of cardiac troponin I (cTnI) is prerequisite for the length-depende...

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Bibliographic Details
Main Authors: Wijnker, Paul J. M., Sequeira, Vasco, Foster, D. Brian, Li, Yuejin, dos Remedios, Cristobal G., Murphy, Anne M., Stienen, Ger J. M., van der Velden, Jolanda
Format: Artigo
Language:Inglês
Published: American Physiological Society 2014
Subjects:
Muscle Mechanics and Ventricular Function
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3989756/
https://ncbi.nlm.nih.gov/pubmed/24585778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00580.2013
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