A direct role of Mad1 in the spindle assembly checkpoint beyond Mad2 kinetochore recruitment

The spindle assembly checkpoint (SAC) ensures accurate chromosome segregation by delaying entry into anaphase until all sister chromatids have become bi-oriented. A key component of the SAC is the Mad2 protein, which can adopt either an inactive open (O-Mad2) or active closed (C-Mad2) conformation....

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Détails bibliographiques
Auteurs principaux: Kruse, Thomas, Larsen, Marie Sofie Yoo, Sedgwick, Garry G, Sigurdsson, Jón Otti, Streicher, Werner, Olsen, Jesper V, Nilsson, Jakob
Format: Artigo
Langue:Inglês
Publié: Blackwell Publishing Ltd 2014
Sujets:
Scientific Reports
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3989694/
https://ncbi.nlm.nih.gov/pubmed/24477933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/embr.201338101
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