A direct role of Mad1 in the spindle assembly checkpoint beyond Mad2 kinetochore recruitment

The spindle assembly checkpoint (SAC) ensures accurate chromosome segregation by delaying entry into anaphase until all sister chromatids have become bi-oriented. A key component of the SAC is the Mad2 protein, which can adopt either an inactive open (O-Mad2) or active closed (C-Mad2) conformation....

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Autori principali: Kruse, Thomas, Larsen, Marie Sofie Yoo, Sedgwick, Garry G, Sigurdsson, Jón Otti, Streicher, Werner, Olsen, Jesper V, Nilsson, Jakob
Natura: Artigo
Lingua:Inglês
Pubblicazione: Blackwell Publishing Ltd 2014
Soggetti:
Scientific Reports
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3989694/
https://ncbi.nlm.nih.gov/pubmed/24477933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/embr.201338101
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