A direct role of Mad1 in the spindle assembly checkpoint beyond Mad2 kinetochore recruitment

The spindle assembly checkpoint (SAC) ensures accurate chromosome segregation by delaying entry into anaphase until all sister chromatids have become bi-oriented. A key component of the SAC is the Mad2 protein, which can adopt either an inactive open (O-Mad2) or active closed (C-Mad2) conformation....

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Bibliographic Details
Main Authors: Kruse, Thomas, Larsen, Marie Sofie Yoo, Sedgwick, Garry G, Sigurdsson, Jón Otti, Streicher, Werner, Olsen, Jesper V, Nilsson, Jakob
Format: Artigo
Language:Inglês
Published: Blackwell Publishing Ltd 2014
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Scientific Reports
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3989694/
https://ncbi.nlm.nih.gov/pubmed/24477933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/embr.201338101
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