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A direct role of Mad1 in the spindle assembly checkpoint beyond Mad2 kinetochore recruitment
The spindle assembly checkpoint (SAC) ensures accurate chromosome segregation by delaying entry into anaphase until all sister chromatids have become bi-oriented. A key component of the SAC is the Mad2 protein, which can adopt either an inactive open (O-Mad2) or active closed (C-Mad2) conformation....
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Blackwell Publishing Ltd
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3989694/ https://ncbi.nlm.nih.gov/pubmed/24477933 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/embr.201338101 |
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