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Stable MCC binding to the APC/C is required for a functional spindle assembly checkpoint
The spindle assembly checkpoint (SAC) delays progression into anaphase until all chromosomes have aligned on the metaphase plate by inhibiting Cdc20, the mitotic co-activator of the APC/C. Mad2 and BubR1 bind and inhibit Cdc20, thereby forming the mitotic checkpoint complex (MCC), which can bind sta...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Blackwell Publishing Ltd
2014
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3989692/ https://ncbi.nlm.nih.gov/pubmed/24464857 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/embr.201337496 |
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