The transcription factor FBI-1 inhibits SAM68-mediated BCL-X alternative splicing and apoptosis

Alternative splicing (AS) is tightly coupled to transcription for the majority of human genes. However, how these two processes are linked is not well understood. Here, we unveil a direct role for the transcription factor FBI-1 in the regulation of AS. FBI-1 interacts with the splicing factor SAM68...

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Autores principales: Bielli, Pamela, Busà, Roberta, Di Stasi, Savino M, Munoz, Manuel J, Botti, Flavia, Kornblihtt, Alberto R, Sette, Claudio
Formato: Artigo
Lenguaje:Inglês
Publicado: Backwell Publishing Ltd 2014
Materias:
Scientific Reports
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3989673/
https://ncbi.nlm.nih.gov/pubmed/24514149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/embr.201338241
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