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The RNA-binding protein Sam68 modulates the alternative splicing of Bcl-x
The RNA-binding protein Sam68 is involved in apoptosis, but its cellular mRNA targets and its mechanism of action remain unknown. We demonstrate that Sam68 binds the mRNA for Bcl-x and affects its alternative splicing. Depletion of Sam68 by RNA interference caused accumulation of antiapoptotic Bcl-x...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2064079/ https://ncbi.nlm.nih.gov/pubmed/17371836 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200701005 |
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