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Alternative Splicing of the Cyclin D1 Proto-Oncogene Is Regulated by the RNA-Binding Protein Sam68

Human cyclin D1 is expressed as two isoforms derived by alternate RNA splicing, termed D1a and D1b, which differ for the inclusion of intron 4 in the D1b mRNA. Both isoforms are frequently upregulated in human cancers, but cyclin D1b displays relatively higher oncogenic potential. The splicing facto...

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Bibliographische Detailangaben
Hauptverfasser: Paronetto, Maria Paola, Cappellari, Manuela, Busà, Roberta, Pedrotti, Simona, Vitali, Roberta, Comstock, Clay, Hyslop, Terry, Knudsen, Karen E., Sette, Claudio
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2884274/
https://ncbi.nlm.nih.gov/pubmed/20028857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-2788
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