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AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

Autophagy is a process by which components of the cell are degraded to maintain essential activity and viability in response to nutrient limitation. Extensive genetic studies have shown that the yeast ATG1 kinase has an essential role in autophagy induction. Furthermore, autophagy is promoted by AMP...

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Bibliographic Details
Main Authors: Kim, Joungmok, Kundu, Mondira, Viollet, Benoit, Guan, Kun-Liang
Format: Artigo
Language:Inglês
Published: 2011
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3987946/
https://ncbi.nlm.nih.gov/pubmed/21258367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb2152
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