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The autophagy initiating kinase ULK1 is regulated via opposing phosphorylation by AMPK and mTOR
The serine/threonine kinase ULK1 is a mammalian homolog of Atg1, part of the Atg1 kinase complex, which is the most upstream component of the core autophagy machinery conserved from yeast to mammals. In budding yeast, activity of the Atg1 kinase complex is inhibited by TORC1 (target of rapamycin com...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Landes Bioscience
2011
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3359466/ https://ncbi.nlm.nih.gov/pubmed/21460621 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.7.6.15123 |
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