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AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

Autophagy is a process by which components of the cell are degraded to maintain essential activity and viability in response to nutrient limitation. Extensive genetic studies have shown that the yeast ATG1 kinase has an essential role in autophagy induction. Furthermore, autophagy is promoted by AMP...

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Autori principali: Kim, Joungmok, Kundu, Mondira, Viollet, Benoit, Guan, Kun-Liang
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3987946/
https://ncbi.nlm.nih.gov/pubmed/21258367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb2152
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