X-ray Structural and Biological Evaluation of a Series of Potent and Highly Selective Inhibitors of Human Coronavirus Papain-like Proteases

[Image: see text] Structure-guided design was used to generate a series of noncovalent inhibitors with nanomolar potency against the papain-like protease (PLpro) from the SARS coronavirus (CoV). A number of inhibitors exhibit antiviral activity against SARS-CoV infected Vero E6 cells and broadened s...

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Hlavní autoři: Báez-Santos, Yahira M., Barraza, Scott J., Wilson, Michael W., Agius, Michael P., Mielech, Anna M., Davis, Nicole M., Baker, Susan C., Larsen, Scott D., Mesecar, Andrew D.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2014
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3983375/
https://ncbi.nlm.nih.gov/pubmed/24568342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm401712t
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