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X-ray Structural and Biological Evaluation of a Series of Potent and Highly Selective Inhibitors of Human Coronavirus Papain-like Proteases
[Image: see text] Structure-guided design was used to generate a series of noncovalent inhibitors with nanomolar potency against the papain-like protease (PLpro) from the SARS coronavirus (CoV). A number of inhibitors exhibit antiviral activity against SARS-CoV infected Vero E6 cells and broadened s...
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| Autors principals: | , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American
Chemical
Society
2014
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| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3983375/ https://ncbi.nlm.nih.gov/pubmed/24568342 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm401712t |
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