Extracellular α-Synuclein Leads to Microtubule Destabilization via GSK-3β-Dependent Tau Phosphorylation in PC12 Cells

α-Synuclein (ASN) plays an important role in pathogenesis of Parkinson's disease (PD) and other neurodegenerative disorders. Novel and most interesting data showed elevated tauopathy in PD and suggested relationship between ASN and Tau protein. However, the mechanism of ASN-evoked Tau protein m...

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Autors principals: Gąssowska, Magdalena, Czapski, Grzegorz A., Pająk, Beata, Cieślik, Magdalena, Lenkiewicz, Anna M., Adamczyk, Agata
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2014
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3983155/
https://ncbi.nlm.nih.gov/pubmed/24722055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0094259
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