Extracellular α-Synuclein Leads to Microtubule Destabilization via GSK-3β-Dependent Tau Phosphorylation in PC12 Cells

α-Synuclein (ASN) plays an important role in pathogenesis of Parkinson's disease (PD) and other neurodegenerative disorders. Novel and most interesting data showed elevated tauopathy in PD and suggested relationship between ASN and Tau protein. However, the mechanism of ASN-evoked Tau protein m...

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Détails bibliographiques
Auteurs principaux: Gąssowska, Magdalena, Czapski, Grzegorz A., Pająk, Beata, Cieślik, Magdalena, Lenkiewicz, Anna M., Adamczyk, Agata
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2014
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3983155/
https://ncbi.nlm.nih.gov/pubmed/24722055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0094259
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