Extracellular Alpha-Synuclein Oligomers Induce Parkin S-Nitrosylation: Relevance to Sporadic Parkinson’s Disease Etiopathology

α-Synuclein (ASN) and parkin, a multifunctional E3 ubiquitin ligase, are two proteins that are associated with the pathophysiology of Parkinson’s disease (PD). Excessive release of ASN, its oligomerization, aggregation, and deposition in the cytoplasm contribute to neuronal injury and cell death thr...

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Detalhes bibliográficos
Publicado no:Mol Neurobiol
Main Authors: Wilkaniec, Anna, Lenkiewicz, Anna M., Czapski, Grzegorz A., Jęśko, Henryk M., Hilgier, Wojciech, Brodzik, Robert, Gąssowska-Dobrowolska, Magdalena, Culmsee, Carsten, Adamczyk, Agata
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6334739/
https://ncbi.nlm.nih.gov/pubmed/29681024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12035-018-1082-0
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