Extracellular α-Synuclein Leads to Microtubule Destabilization via GSK-3β-Dependent Tau Phosphorylation in PC12 Cells

α-Synuclein (ASN) plays an important role in pathogenesis of Parkinson's disease (PD) and other neurodegenerative disorders. Novel and most interesting data showed elevated tauopathy in PD and suggested relationship between ASN and Tau protein. However, the mechanism of ASN-evoked Tau protein m...

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Detalhes bibliográficos
Main Authors: Gąssowska, Magdalena, Czapski, Grzegorz A., Pająk, Beata, Cieślik, Magdalena, Lenkiewicz, Anna M., Adamczyk, Agata
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3983155/
https://ncbi.nlm.nih.gov/pubmed/24722055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0094259
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