Extracellular α-Synuclein Leads to Microtubule Destabilization via GSK-3β-Dependent Tau Phosphorylation in PC12 Cells

α-Synuclein (ASN) plays an important role in pathogenesis of Parkinson's disease (PD) and other neurodegenerative disorders. Novel and most interesting data showed elevated tauopathy in PD and suggested relationship between ASN and Tau protein. However, the mechanism of ASN-evoked Tau protein m...

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Main Authors: Gąssowska, Magdalena, Czapski, Grzegorz A., Pająk, Beata, Cieślik, Magdalena, Lenkiewicz, Anna M., Adamczyk, Agata
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2014
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3983155/
https://ncbi.nlm.nih.gov/pubmed/24722055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0094259
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