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A pathway linking oxidative stress and the Ran GTPase system in progeria

Maintaining the Ran GTPase at a proper concentration in the nucleus is important for nucleocytoplasmic transport. Previously we found that nuclear levels of Ran are reduced in cells from patients with Hutchinson–Gilford progeria syndrome (HGPS), a disease caused by constitutive attachment of a mutan...

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Bibliografiske detaljer
Main Authors: Datta, Sutirtha, Snow, Chelsi J., Paschal, Bryce M.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Cell Biology 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3982987/
https://ncbi.nlm.nih.gov/pubmed/24523287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E13-07-0430
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