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Defective nuclear import of Tpr in Progeria reflects the Ran sensitivity of large cargo transport

The RanGTPase acts as a master regulator of nucleocytoplasmic transport by controlling assembly and disassembly of nuclear transport complexes. RanGTP is required in the nucleus to release nuclear localization signal (NLS)–containing cargo from import receptors, and, under steady-state conditions, R...

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Main Authors: Snow, Chelsi J., Dar, Ashraf, Dutta, Anindya, Kehlenbach, Ralph H., Paschal, Bryce M.
格式: Artigo
語言:Inglês
出版: The Rockefeller University Press 2013
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3653351/
https://ncbi.nlm.nih.gov/pubmed/23649804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201212117
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