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Defective nuclear import of Tpr in Progeria reflects the Ran sensitivity of large cargo transport

The RanGTPase acts as a master regulator of nucleocytoplasmic transport by controlling assembly and disassembly of nuclear transport complexes. RanGTP is required in the nucleus to release nuclear localization signal (NLS)–containing cargo from import receptors, and, under steady-state conditions, R...

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Tallennettuna:
Bibliografiset tiedot
Päätekijät: Snow, Chelsi J., Dar, Ashraf, Dutta, Anindya, Kehlenbach, Ralph H., Paschal, Bryce M.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: The Rockefeller University Press 2013
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3653351/
https://ncbi.nlm.nih.gov/pubmed/23649804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201212117
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