The Defective Nuclear Lamina in Hutchinson-Gilford Progeria Syndrome Disrupts the Nucleocytoplasmic Ran Gradient and Inhibits Nuclear Localization of Ubc9

The mutant form of lamin A responsible for the premature aging disease Hutchinson-Gilford progeria syndrome (termed progerin) acts as a dominant negative protein that changes the structure of the nuclear lamina. How the perturbation of the nuclear lamina in progeria is transduced into cellular chang...

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Hoofdauteurs: Kelley, Joshua B., Datta, Sutirtha, Snow, Chelsi J., Chatterjee, Mandovi, Ni, Li, Spencer, Adam, Yang, Chun-Song, Cubeñas-Potts, Caelin, Matunis, Michael J., Paschal, Bryce M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology 2011
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3147792/
https://ncbi.nlm.nih.gov/pubmed/21670151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.05087-11
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